The SEYA Building is located on the border of the Highlandtown and Canton neighborhoods in Eastern Baltimore City. Highlandtown is one of the most diverse neighborhoods in Baltimore, and the main thoroughfare in the neighborhood, Eastern Avenue, is designated as a Main Street District. Eastern Avenue boasts a variety of restaurants, retail stores, and numerous art and cultural destinations that cater to over 250,000 visitors yearly.
Major employers nearby include Johns Hopkins Hospital (Main and Bayview Campuses), CareFirst BlueCross BlueShield, and 1st Mariner Bank. The central location of the site, as well as its accessibility to public transportation and main city thoroughfares, makes it easily accessible to the Central Business District, Fells Point, Harbor East, and the suburbs of Baltimore City.
The Canton and Highlandtown areas remain as one of the most densely populated areas in Baltimore City, offering a wide array of housing and shopping options for residents.