Office Space for Rent Monroe County

518 Duval St

1 Space, 1 - 17 ^ppl

(2,155^SF)

From $2,783,541

Located on the world-famous Duval Street, indulge in the eclectic dining experiences, explore local art galleries, and soak up the island's rich culture. With close proximity to renowned landmarks like the Ernest Hemingway Home and Museum, the Key West Butterfly and Nature Conservatory, and the iconic Southernmost Point, tenants at the property will enjoy a dynamic work-life balance. The surrounding area offers a blend of historic architecture, lush tropical landscapes, and a lively atmosphere, making it an ideal location for office tenants seeking inspiration and leisure in their professional environment.

425 Eaton St

1 Space, 1 - 3 ^ppl

(385^SF)

Located on bustling Eaton Street in the heart of Old Town Key West, this compact office suite sits just steps from world-famous Duval Street. The area is surrounded by restaurants, boutiques, galleries, and professional offices, drawing steady pedestrian and vehicle traffic. Its central position offers excellent visibility and walkability, making it ideal for a small business, studio, or professional office seeking a prominent Old Town address.

1213 Truman Ave

1 Space, 1 - 8 ^ppl

(1,020^SF)

Situated in the heart of Key West’s Old Town district, this property sits along Truman Avenue, a main connector road that carries residents and visitors between the island’s residential neighborhoods and its commercial core. The building benefits from a mix of nearby government offices, established local businesses, and walkable residential streets, creating a steady flow of daytime activity. Its central placement also allows quick access to downtown Key West, the courthouse and Harvey Government Center across the street, and the island’s major east–west corridors.

Conch Harbor

951 Caroline St

2 Spaces, 1 - 10 ^ppl

(115 - 1,200^SF)

Located in the Conch Harbor Retail Center at the corner of Caroline and Grinnell Streets, this property sits in a highly desirable Old Town Key West location with strong foot and vehicle traffic. The center is home to popular destinations such as Prime 951 Steakhouse, Dante’s Pool Bar & Restaurant, and West Marine, drawing a steady mix of locals, boaters, and visitors year-round. The property also benefits from its waterfront setting and proximity to the Historic Seaport, one of Key West’s busiest commercial and leisure districts. Metered parking and a shared courtyard with outdoor seating make this an attractive and convenient spot for small businesses seeking a central Old Town address.

1010 Kennedy Dr

2 Spaces, 1 - 16 ^ppl

(1,475 - 2,058^SF)

Situated in the heart of New Town, Key West, this office condo enjoys a convenient and highly accessible location just off Kennedy Drive at Mile Marker 3. The property is part of the well-established Kennedy Center, a professional office building that serves a wide variety of local businesses, medical providers, and service firms. With its central New Town setting, tenants benefit from proximity to residential neighborhoods, shopping centers, and government offices, as well as quick access to both Old Town and Stock Island. The building’s off-street parking and elevator access make it a practical choice for employees and clients alike.

524 Eaton Street

2 Spaces, 1 - 2 ^ppl

(232 - 320^SF)

Located in the heart of Old Town Key West, 524 Eaton Street places you just steps from Duval Street, the Courthouse, and the island’s central business district. The property is situated within the Key West Theater building, offering a unique professional setting surrounded by restaurants, shops, and cultural landmarks. This prime Old Town address provides excellent walkability and convenience for both local clients and professionals.

21460 Overseas Highway

2 Spaces, 1 - 7 ^ppl

(750 - 862^SF)

Located directly on US Highway 1 at Mile Marker 21 in Cudjoe Key, this professional office building offers excellent visibility and convenient access for Lower Keys businesses. Positioned midway between Key West and Marathon, the property provides a strategic location to serve clients throughout the region. The building is elevator-served, with ample off-street parking, and is surrounded by a mix of commercial services and residential communities, making it an ideal base for professional and service-oriented tenants.

9141 Overseas Highway

1 Space, 1 ^ppl

(83^SF)

Discover a vibrant location in the heart of the Florida Keys at the address provided. Nestled in Marathon, FL, this area offers a unique blend of laid-back island charm and modern amenities. With easy access to the Overseas Highway, businesses can thrive in this bustling coastal community. Enjoy the convenience of nearby dining options, captivating marine life at the Florida Keys Aquarium Encounters, and the natural beauty of Curry Hammock State Park. Your team will appreciate the work-life balance found at this ideal location. Embrace the island lifestyle and connect with a welcoming community at this prime address.