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Office Space for Rent Roanoke

Clearbrook Office Building

5304 Indian Grave Rd

2 Spaces, 1 - 24 ^ppl

(2,350 - 3,000^SF)

From $3,133/MO

From Downtown, South on US 220 to right on Indian Grave Road. Signalized intersection.

Brambleton Health Pavilion

4633 Brambleton Avenue

1 Space, 1 - 14 ^ppl

(1,800^SF)

From $2,550/MO

2 stoplights south of US Rt 419.

The Oaks

3826 Thirlane Rd NW

3 Spaces, 1 - 69 ^ppl

(3,538 - 8,614^SF)

From $4,422/MO

Great proximity to Roanoke-Blacksburg Regional Airport, I-581, I-81, the Valley View Mall district and Downtown Roanoke. Conveniently located in a quiet area between two major North Roanoke traffic arteries (Hershberger Road and Peters Creek Road), both with direct I-581 access.

Franklin Road Second Level Office Suite

3904 Franklin Road

1 Space, 1 - 46 ^ppl

(5,700^SF)

From $5,700/MO

Superlatively convenient to US 220 and SR 419--Two traffic arteries that traverse and connect the greater Roanoke area. In close proximity to affluent residential areas, Tanglewood Mall, Downtown Roanoke, and other diverse retail, business and restaurant entities. Less than 15 mins from the Roanoke-Blacksburg Regional Airport, the Valley View Mall area and I-81.

Adaptable Roanoke City Office Space

4311 Appleton Ave NW

1 Space, 1 - 31 ^ppl

(3,917^SF)

From $3,917/MO

Conveniently located immediately off Peters Creek Rd. Only 10 mins from Salem, Downtown Roanoke and Valley View Mall, this property is easily accessible from I-581 and I-81. Surrounded by both major retailers and densely populated residential areas, an estimated 17,000 vehicles pass by Appleton Avenue on Peters Creek Rd every day (VDOT AADT 2024 Roanoke County).

Professional Arts Building

30 Franklin Rd

4 Spaces, 1 - 13 ^ppl

(660 - 1,611^SF)

From $1,017/MO

Easily accessible and within walking distance to the heart of downtown Roanoke.

Creekside Center

631 Peters Creek Rd NW

5 Spaces, 1 - 14 ^ppl

(1,400 - 1,750^SF)

From $1,400/MO

Located at the corner of Shenandoah Avenue and Peters Creek Rd with a signaled intersection.

Brandon Point Office Building

3807 Brandon Avenue SW

4 Spaces, 1 - 50 ^ppl

(1,375 - 6,200^SF)

From $1,546/MO

Brandon Point Office Building is a located in the southwest Roanoke office market. It offers close proximity to Lewis Gale Hospital, Electric Road/Rt 419, the Peters Creek Road corridor, VA Medical Center, and numerous well-established neighborhoods.

2727 Franklin Road, SW

1 Space, 1 - 87 ^ppl

(10,923^SF)

From $11,605/MO

The property lies within a cluster of medical, research and professional facilities and is exceptionally connected with direct access to I‑581 and US 220 approximately a mile west.

3441 Brandon Ave SW

1 Space, 1 - 146 ^ppl

(18,200^SF)

From $4,550/MO

Located on heavily trafficked Brandon Ave, this space is conveniently located for any business serving Southwest County, Downtown, and most other major areas of Roanoke.

1125 South Jefferson St.

1 Space, 1 - 30 ^ppl

(3,272^SF)

From $3,272/MO

1125 South Jefferson is an excellent office opportunity located just outside downtown Roanoke. Enjoy close proximity to a variety of dining options, perfect for client lunches or after-work gatherings. Take advantage of cultural attractions like the Taubman Museum of Art and the historic Roanoke City Market, offering opportunities for client entertainment and leisurely exploration.

Downtown Roanoke Office

312 S Jefferson St

1 Space, 1 - 9 ^ppl

(1,150^SF)

Introducing 312 S Jefferson Street, Roanoke, VA — a well-positioned office or retail opportunity in the core of Downtown Roanoke. The property benefits from strong pedestrian activity and prominent street visibility along a primary downtown corridor. Surrounded by a mix of established financial institutions, specialty retailers, dining destinations, and professional service providers — including HomeTrust Bank, Mast General Store, Milans, Well Hung Vineyard, and Elderberries — the location offers a dynamic business environment that supports both customer engagement and day-to-day operational convenience.

25 Franklin Road

1 Space, 1 - 48 ^ppl

(3,141^SF)

From $2,617/MO

25 Franklin Road is strategically located between 1st street and Jefferson street in downtown Roanoke. Across the Street from the Shenandoah Club, and near Paul's Restaurant.

Parkway 301

301 1st Street Southwest

1 Space, 1 - 45 ^ppl

(5,612^SF)

Parkway 301 is located on 1st Street in the core of Downtown Roanoke, VA

First Campbell Square

34 Campbell Ave SW

6 Spaces, 1 - 140 ^ppl

(1,600 - 17,560^SF)

From $1,866/MO

Located at the corner of Campbell Avenue and First Street in downtown Roanoke.

North Roanoke Plaza

3100 Peters Creek Road

3 Spaces, 1 - 7 ^ppl

(650 - 815^SF)

From $758/MO

Peters Creed Rd is a main traffic thoroughfare and is convenient to I-581 and I-81.

South Roanoke Location with Parking

301 McClanahan Street SW

3 Spaces, 1 - 50 ^ppl

(3,300 - 6,631^SF)

From $4,125/MO

Property located in South Roanoke at 301 McClanahan Street SW adjacent to the main campus of Carilion Roanoke Memorial Hospital

First Citizens Bank Building

110 Church Ave

2 Spaces, 1 - 96 ^ppl

(1,007 - 12,000^SF)

From $1,510/MO

Downtown Roanoke, On the corner of Church and 1st ST.

1713 Plantation Rd NE

1 Space, 1 - 400 ^ppl

(50,000^SF)

From $14,585/MO

Located on Plantation Road just a few minutes from Downtown Roanoke.

Newly Renovated Downtown Office Space

114 Day Avenue Southwest

1 Space, 1 - 12 ^ppl

(1,475^SF)

From $1,720/MO

Located on the edge of Downtown Roanoke with incredible views of the Central Business District.

5251 Concourse Valleypointe

5251 Concourse Dr

1 Space, 1 - 49 ^ppl

(6,150^SF)

From $7,687/MO

Located just off I-581 and I-81. Roanoke Regional Airport is within half a mile drive.