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Office Space for Rent Cape Girardeau County

5841 State Highway K

1 Space, 1 - 12 ^ppl

(1,440^SF)

Located on high traffic and visibility State Highway K

213 Clark Avenue

1 Space, 1 - 9 ^ppl

(1,172^SF)

Central Cape Girardeau location just a couple of blocks off of Kingshighway and Independence St.

221 Merriwether Street

1 Space, 1 - 10 ^ppl

(1,300^SF)

Located in downtown Cape one block off of S. Spanish St.

122 S. Spanish St.

1 Space, 1 - 42 ^ppl

(5,225^SF)

Downtown Cape Girardeau central business district

301 Broadway St

5 Spaces, 1 - 29 ^ppl

(1,250 - 3,600^SF)

301 Broadway is centrally located in the heart of downtown Cape Girardeau, one of Southeast Missouri’s most vibrant and walkable business districts. The property sits among a dynamic mix of restaurants, retail, and entertainment venues, offering convenience and energy for both employees and clients. The historic Missourian Building has long been a cornerstone of the community and continues to serve as a hub for business and media activity. Its prime location places tenants within walking distance of key amenities and just minutes from major transportation routes. Strategically positioned between St. Louis and Memphis, Cape Girardeau provides regional accessibility while maintaining a strong local workforce and business environment. Nearby parking and multiple access points make commuting and client visits simple and efficient.

Up to 2,580 SF of Lease Space Available

106 Farrar Drive

1 Space, 1 - 21 ^ppl

(2,580^SF)

Located in the west part of Cape Girardeau near I-55.

Office/Retail Space For Lease

440 S. Mount Auburn Road

1 Space, 1 - 9 ^ppl

(1,184^SF)

Excellent location on S. Mount Auburn Road near the interchange of I-55 and Highway 74

13,694 SF Commercial Building in Historic Downtown

18 N. Main

1 Space, 1 - 110 ^ppl

(13,694^SF)

Located in historic downtown Cape Girardeau on the riverfront.

301 South Broadview Street

1 Space, 1 - 121 ^ppl

(15,100^SF)

The area surrounding the property is a bustling hub for retail and dining experiences. Just a short stroll from the location, you'll find a diverse selection of boutiques, specialty stores, and popular dining establishments. From charming cafes to trendy eateries, the neighborhood offers a rich tapestry of culinary delights to explore. Whether it's a quick coffee break, a casual lunch, or a fine dining experience, the area boasts an array of options to satisfy every craving. With its vibrant retail scene and culinary diversity, the location sets the stage for a dynamic and inviting environment for business and leisure alike.

Center Pointe Commons

151 S Mount Auburn Rd

1 Space, 1 - 16 ^ppl

(1,250^SF)

Great visibility location near I-55, hospital, hotels and restaurants

2441 Myra Dr

2 Spaces, 1 - 16 ^ppl

(440 - 520^SF)

From $550/MO

2441 Myra Drive is strategically located in the heart of Cape Girardeau’s established commercial and medical corridor, just off Kingshighway—one of the city’s primary north-south thoroughfares. The surrounding area features a strong concentration of retail, dining, and service-oriented businesses, as well as dense residential neighborhoods that provide a steady and diverse patient base. The property’s central location offers convenient access from multiple directions, making it easy for clients and patients to visit. Its proximity to major traffic routes and nearby amenities enhances both visibility and accessibility, while the professional setting makes it a natural fit for medical and wellness users seeking a reputable Cape Girardeau address.

1,218 SF Professional Office Building

720 Forest Ave

1 Space, 1 - 10 ^ppl

(1,218^SF)

Good Professional Office Area Off Broadway.

Auburn Park

3065 William

4 Spaces, 1 - 34 ^ppl

(775 - 4,273^SF)

Excellent location right off I-55 and near restaurants, mall and retail.