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Office Space for Rent Cape Girardeau

301 Broadway St

1 Space, 1 - 21 ^ppl

(2,600^SF)

From $5,633/MO

301 Broadway is centrally located in the heart of downtown Cape Girardeau, one of Southeast Missouri’s most vibrant and walkable business districts. The property sits among a dynamic mix of restaurants, retail, and entertainment venues, offering convenience and energy for both employees and clients. The historic Missourian Building has long been a cornerstone of the community and continues to serve as a hub for business and media activity. Its prime location places tenants within walking distance of key amenities and just minutes from major transportation routes. Strategically positioned between St. Louis and Memphis, Cape Girardeau provides regional accessibility while maintaining a strong local workforce and business environment. Nearby parking and multiple access points make commuting and client visits simple and efficient.

301 Broadway St

1 Space, 1 - 10 ^ppl

(1,250^SF)

From $2,604/MO

301 Broadway sits in the core of downtown Cape Girardeau, surrounded by a vibrant mix of local restaurants, boutiques, and entertainment venues. This walkable district provides an energetic setting that enhances both employee experience and client engagement. The Missourian Building is one of the city’s most recognizable landmarks, blending historic charm with modern office and retail users. Its central location ensures convenient access to daily amenities, while nearby parking options make commuting simple. Strategically located between St. Louis and Memphis, Cape Girardeau offers strong regional connectivity along with a growing business community—making it an ideal place for companies to establish or expand their presence.

122 S. Spanish St.

1 Space, 1 - 42 ^ppl

(5,225^SF)

Downtown Cape Girardeau central business district

5841 State Highway K

1 Space, 1 - 12 ^ppl

(1,440^SF)

Located on high traffic and visibility State Highway K

221 Merriwether Street

1 Space, 1 - 10 ^ppl

(1,300^SF)

Located in downtown Cape one block off of S. Spanish St.

Auburn Park

3065 William

4 Spaces, 1 - 34 ^ppl

(775 - 4,273^SF)

Excellent location right off I-55 and near restaurants, mall and retail.

Office/Retail Space For Lease

440 S. Mount Auburn Road

1 Space, 1 - 9 ^ppl

(1,184^SF)

Excellent location on S. Mount Auburn Road near the interchange of I-55 and Highway 74

2441 Myra Dr

1 Space, 1 - 16 ^ppl

(2,000^SF)

From $2,500/MO

2441 Myra Drive is strategically located in the heart of Cape Girardeau’s established commercial and medical corridor, just off Kingshighway—one of the city’s primary north-south thoroughfares. The surrounding area features a strong concentration of retail, dining, and service-oriented businesses, as well as dense residential neighborhoods that provide a steady and diverse patient base. The property’s central location offers convenient access from multiple directions, making it easy for clients and patients to visit. Its proximity to major traffic routes and nearby amenities enhances both visibility and accessibility, while the professional setting makes it a natural fit for medical and wellness users seeking a reputable Cape Girardeau address.

Lorimont Place Development

240-276 S. Mount Auburn Road

1 Space, 1 - 63 ^ppl

(7,857^SF)

Located in a great professional complex near I-55, hotels & restaurants.

1,218 SF Professional Office Building

720 Forest Ave

1 Space, 1 - 10 ^ppl

(1,218^SF)

Good Professional Office Area Off Broadway.

600 SF Commercial Lease Space

2222 Kingsway Dr, Suite C

1 Space, 1 - 5 ^ppl

(600^SF)

Located in North Cape Girardeau near Broadway & Kingshighway.

301 South Broadview Street

1 Space, 1 - 121 ^ppl

(15,100^SF)

The area surrounding the property is a bustling hub for retail and dining experiences. Just a short stroll from the location, you'll find a diverse selection of boutiques, specialty stores, and popular dining establishments. From charming cafes to trendy eateries, the neighborhood offers a rich tapestry of culinary delights to explore. Whether it's a quick coffee break, a casual lunch, or a fine dining experience, the area boasts an array of options to satisfy every craving. With its vibrant retail scene and culinary diversity, the location sets the stage for a dynamic and inviting environment for business and leisure alike.

Center Pointe Commons

151 S Mount Auburn Rd

1 Space, 1 - 16 ^ppl

(1,250^SF)

Great visibility location near I-55, hospital, hotels and restaurants