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Office Space for Rent Durham

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Spaces Durham - Mangum St

555 S Mangum Street Suite 100

3 Spaces , 1 - 29 ^ppl

$299 - $505^/MO

The business center in Mangum Street is part of a landscape-changing new development at the heart of Durham city centre a mainline into the business world of North Carolina and beyond. This is a workspace for creative professionals, dynamic corporate players, and graduating entrepreneurs from nearby Duke University. It facilitates these change-makers with its fantastic selection of private offices, meeting rooms and flexible workspaces. From the site’s rooftop terrace, you overlook the Durham Bulls Athletic Park stadium, with a view so good, you could almost catch a home run right from your office. But even if you are not a sports fan, the relaxed vibe and casual atmosphere can help you feel at home here. Creature comforts are enhanced by the super-fast Wi-Fi connections, barista-brewed coffee, and friendly reception staff ready to help you achieve your goals.

Venture X

600 Park Offices Drive Suite 300

4 Spaces, 1 - 26 ^ppl

(up to 962^SF)

Coworking from $99/MO

The modern designed space has high exposed ceilings with an industrial loft design, a large lounge area with a café and hi-tech meeting rooms, and high-speed internet. This location in Durham is a modern coworking space offering its members a shared, flexible workspace with a community of like-minded business professionals. Members include entrepreneurs, established businesses, startups, and small- to medium-sized businesses. Dedicated community managers provide boutique hotel-style hospitality, advocating for your business success with concierge-level member services and 24/7 secure access. This space also houses a fully furnished wellness room specifically designed for new working mothers or those in need of a private space to tend to other personal health needs.

Regus Durham - Meridian Pkwy

2530 Meridian Parkway Suite 300

3 Spaces, 1 - 41 ^ppl

(up to 30,000^SF)

Coworking from $239/MO

This state of the art and fully functional business center installation is set within a contemporary landmark office building with an impressive frontage and a stylish architectural design. This center provides a range of flexible serviced office space to cater for any type or size of specific corporate business need and workspace requirement. Inside, this center is fully furnished and air conditioned. The building also offers a wide range of fantastic facilities and professional provisions including spacious meeting rooms, conferencing capabilities, high speed internet connectivity, dedicated corporate telephony and more.

HJK LLC

1912, North Carolina 54

1 Space, 10 ^ppl

(297^SF)

From $450/MO

Professional Office / Flex Space Available in RTP – Flexible Lease Options: Discover a premium office/flex space in the heart of Research Triangle Park (RTP), comprising Suite C (2,500 sq. ft.) and Suite C2 (700 sq. ft.). These highly versatile suites can be leased separately or together, offering the perfect solution for growing teams, satellite offices, or multiple departments seeking professional, efficient, and flexible workspace. Property Details • Address: 1912 E NC Hwy 54, Suites C & C2, Durham, NC 27713 • Suite Sizes: Suite C = 2,500 sq.ft| Suite C2 = 700 sq.ft • Total Available Space: 3,200 sq.ft • Availability: February 1, 2026 • Use: Office / Flex

Regus Durham - Shannon Rd

3511 Shannon Road

4 Spaces, 7 ^ppl

Coworking from $179/MO

This modern office space has a range of social coworking areas and serviced offices available, all come fully equipped with beautiful furniture and are ready to move into. The center is accessible 24 hours a day so the clients can work flexibly. This workspace has spacious meeting rooms completely filled with natural lights to keep the members energetic and enthusiastic. Moreover, this workspace provides an abundance of amenities such as high-speed internet, a business lounge, break-out areas, copying, and printing facilities. In addition, a kitchen is also available inside the building where members can grab snacks and beverages.

Regus Durham - Emperor Blvd

4819 Emperor Boulevard Suite 400

3 Spaces, 1 - 12 ^ppl

(up to 30,000^SF)

Coworking from $229/MO

This prestigious and contemporary business center installation offers all prospective tenants and professionals with a prominent business address that features individual offices, suites and team rooms which are ideal to fulfil any type of corporate requirement. The center's contemporary décor supports the RTP cutting-edge image. It includes three technologically equipped and spacious meeting rooms and a training center ideal for a number of training functions and professional purposes. The site also features high speed internet, dedicated corporate telephony, copy and printing equipment and much more.

Durham Bottling Co

506 Ramseur Street Suite 1

2 Spaces, 1 - 5 ^ppl

Coworking from $300/MO

The center is dedicated to building a membership base and an environment that is welcoming, impactful, and growing. More than just technology, the center is dedicated to providing a useful and secure home base for non-profits, freelancers, creatives, entrepreneurs, new small enterprises, and teams as they grow into the powerful roles that they will undoubtedly play in the city and beyond. It is transformed into a modern industrial workspace that has dynamic seating options, private corners, meeting space, conference rooms, dedicated event space, and a wide selection of private office suites. Large windows and skylights help light the space through the day, and warm lamps and varied lighting illuminate in the evening the night owls. In addition, the workspace allows clients to have 24-hour access 7 days out of every week with high-speed Wi-Fi accessible all through the center.

3LO

120 East Parrish Street Suite 310

2 Spaces, 1 - 10 ^ppl

(up to 111^SF)

Coworking from $199/MO

Nestled in the heart of Downtown Durham’s historic City Center district, this inspiring co-working and meeting hub offers the perfect blend of functionality, collaboration, and aesthetic appeal. Located in the iconic Law Building on the renowned Black Wall Street, the space is surrounded by vibrant energy, including trendy restaurants, startups, venture capital firms, and local landmarks like DPAC just two blocks away.

One City Center

101 Corcoran Street

3 Spaces, 1 - 251 ^ppl

(5,717 - 31,321^SF)

One City Center is where Durham connects. One City Center brings together office, residential, and retail in the center of Downtown Durham. Positioned at Main and Corcoran Streets, the mixed-use development connects directly to the city’s dining, entertainment, hospitality, and business districts. Welcome to an urban environment that is active throughout the day. With 9 retailers on-site, nearby destinations include popular restaurants, Durham Performing Arts Center, and Durham Bulls Stadium. Direct connectivity to NC-147, I-40, I-85, and I-540 links One City Center to RTP, Raleigh, RDU International Airport, and the Triangle’s major employment centers and workforce neighborhoods.

3333 Durham-Chapel Hill Blvd

1 Space, 1 - 8 ^ppl

(1,000^SF)

Located in the South Square area of Durham, surrounding by shopping and restaurants.

Croasdaile Office Park

1816 Front Street, Suite 220

1 Space, 1 - 24 ^ppl

(3,000^SF)

From $4,687/MO

Located in north Durham, Croasdaile Office Park is surrounded by a variety of retail and service businesses and offers convenient access to I-85/US 70 (±0.2 miles), Duke University/Medical Center (±2 miles), and downtown (±4 miles).

706 Ninth Street

1 Space, 1 - 29 ^ppl

(1,497^SF)

Close proximity to Duke University and Medical Center, Durham VA Medical Center, Downtown Durham, NC-147, I-85

Roxboro Road Professional Center

4210 N. Roxboro Street, Suite 140

1 Space, 1 - 19 ^ppl

(2,408^SF)

From $4,113/MO

2919 Colony Road

1 Space, 1 - 31 ^ppl

(3,867^SF)

From $6,445/MO

YORKSHIRE PLACE

4307 Emperor Boulevard

3 Spaces, 1 - 223 ^ppl

(1,601 - 27,822^SF)

From $3,935/MO

A three-story office building located in the award-winning Imperial Center Business Park. Minutes from I-40, I-540, RDU International Airport, and numerous surrounding amenities.

Winchester Place

4309 Emperor Blvd.

6 Spaces, 1 - 159 ^ppl

(3,111 - 20,208^SF)

From $7,907/MO

A four-story building located in the award-winning Imperial Center Business Park. Minutes from I-40, I-540, RDU International Airport and numerous surrounding amenities.

Bristol Place

4819 Emperor Blvd.

3 Spaces, 1 - 138 ^ppl

(2,888 - 17,331^SF)

From $13,694/MO

A four-story office building located in the award-winning Imperial Center Business Park. Minutes from I-40, I-540, RDU International Airport and numerous surrounding amenities.

Brighton Hall

1101 Slater Road

4 Spaces, 1 - 61 ^ppl

(2,298 - 7,519^SF)

From $5,840/MO

Located in the award-winning Imperial Center Business Park. Minutes from I-40, I-540, RDU Airport, and numerous surrounding amenities.

1212 Broad Street, Suite B

1 Space, 1 - 11 ^ppl

(1,356^SF)

n/a

±2,080 SF Office Condo | University Office Park

411 Andrews Rd, STE 110 & 120

1 Space, 1 - 17 ^ppl

(2,080^SF)

From $3,120/MO

411 Andrews Rd sits in University Office Park off Morreene Rd in Durham's 27705, minutes from the US 15-501 and NC-147 interchange and near Duke University.

High-Visibility CG-Zoned Commercial Building | Hillsborough Rd Corridor | Minutes to Duke University & Downtown Durham

2810 Hillsborough Rd

1 Space, 1 - 24 ^ppl

(2,978^SF)

From $4,467/MO

Located along Hillsborough Road (US-70) in Durham's Old West Durham neighborhood, the property sits at the convergence of urban infill momentum and institutional demand. The corridor provides seamless connectivity westward to I-85 and eastward into the heart of Downtown Durham — placing tenants within minutes of Durham's financial core, entertainment district, and live-work-play developments. Duke University's main campus lies approximately 1 mile to the southwest, generating a sustained pipeline of student, faculty, and medical traffic. Duke University Medical Center and the broader health system campus anchor demand within the immediate trade area. The Raleigh-Durham International Airport is accessible within approximately 26 minutes via NC-147, serving one of the Southeast's most active air markets. The property also benefits from proximity to the Durham Performing Arts Center, Durham Bulls Athletic Park, and the Nine—a rapidly developing urban district — solidifying the corridor's commercial vitality.

Golden Belt Campus

807 E Main St & 800 Taylor St

8 Spaces, 1 - 129 ^ppl

(1,110 - 16,158^SF)

Downtown Durham

±1,000 SF Bldg 400, Suite D Office Near RTP – Durham, NC

1910 Sedwick Rd, BLDG 400

1 Space, 1 - 9 ^ppl

(1,000^SF)

Located in South Durham's Research Triangle submarket near the Sedwick Rd/Apex Hwy (NC-55) intersection. Minutes from RTP via Hwy 55, Hwy 54, and I-40, with nearby restaurants, retail, and extended-stay hotels. RDU International Airport is a 16-minute drive.

Two 2nd-Floor Office Suites Near RTP | Bldg 100, Durham

1910 Sedwick Rd, BLDG 100

2 Spaces, 1 - 8 ^ppl

(1,030 - 1,030^SF)

Suite C | 1,030 SF Office Suite in Prime Durham Location

1910 Sedwick Rd

1 Space, 1 - 8 ^ppl

(1,030^SF)

From $1,545/MO

This property is located in a prime Durham area, just minutes from RTP and easily accessible via Hwy 55, Hwy 54, and I-40. Surrounded by a variety of restaurants and shops.