Office Space for Lease South Carolina

46 State St

From $4,500/MO

Located in the heart of historic Downtown Charleston, 46 State Street, Unit B offers a rare opportunity to lease approximately 1,500 square feet of charming office or retail space in one of the city’s most desirable and walkable locations. Situated just off Queen Street and Cumberland, the property is surrounded by Charleston’s renowned restaurants, boutique retailers, hotels, galleries, and historic destinations, providing an exceptional setting for businesses looking to establish a presence in the heart of the Peninsula.

Regus Rock Hill - Technology Ctr Way

300 Technology Center Way 2nd floor

Coworking from $119/MO

The construction team is currently developing this location, adding another site to a global network of over 4,000 that enables people worldwide to work closer to where work needs to happen. Further details about this location will be available soon. Each workspace promotes professionalism and productivity, featuring ergonomic furniture, ambient lighting, and essential on-site facilities, including shared amenities such as kitchens and breakout spaces. Workspaces accommodate a variety of workstyles—whether using a business lounge, coworking area, office for the day, or meeting room by the hour. Long-term options include ready-to-use or fully customizable offices, as well as dedicated coworking desks. Every location can also serve as a business postal address through a Virtual Office setup.

Regus Rock Hill - East Main St

331 E. Main Street Suite 200

Coworking from $449/MO

In an accessible Rock Hill location, this contemporary and technologically sophisticated business center installation is opening soon and is surrounded by numerous successful businesses and globally renowned blue chip companies from an increasingly manufacturing and retail-driven economy, all present as commercial residents and occupying clients within this expansive corporate district. The center offers a range of professional facilities and services including spacious meeting rooms, high speed internet connectivity, on-site management, secure parking provision, administrative support and benefits from an abundance of natural light.

Regus Easley - East Main St

900 E. Main Street 2nd Floor

Coworking from $49/MO

Ensure business ambitions are heading in the right direction with modern office space in Easley, South Carolina. The service sector drives 83.7% of the economy, and many large corporations have chosen to establish their presence here. Whether for quick meetings or long-term projects, the perfect space is available. All the foundations are in place to build a winning business team and foster strong client relationships in South Carolina. Park in one of the free onsite parking spots and get started immediately, surrounded by calm settings and large windows that let in natural light to enhance focus. Seamlessly connect to business-grade WiFi while enjoying the flexibility to work in fully furnished coworking spaces, stylish meeting rooms, and quiet private offices.

Regus Columbia - N. Stadium Blvd

303 N Stadium Blvd 2nd Floor

Coworking from $279/MO

This business center offers unique business space in a retail hotspot in Columbia, Missouri - an economic area experiencing tremendous growth. The district includes several shopping malls (Columbia Mall and Crossroads West Shopping Center), which also offer business amenities such as banks and law firms. Key employers in Columbia are the University of Missouri, schools and hospitals, insurance companies, food and beverage manufacturers, laboratories specializing in science and technology, and construction. It is also home to a start-up in the mortgage industry that is now one of the state's largest private employers.

Venture X

885 Gold Hill Road

From $549/MO

Venture X Fort Mill – Wilson Farms encompasses over 18,000 square feet, providing ample space for your business to thrive. Venture X Fort Mill has a contemporary layout structure across two floors. With 85 total offices accommodating nearly 300 dedicated desks, our flexible office layout is designed to suit diverse needs and can be reconfigured for your team’s size. Choose from our array of options, including four team suites for larger groups, single and double offices, as well as offices of varying sizes for teams. We cater to every requirement, ensuring a workspace that perfectly aligns with your vision. At Venture X Fort Mill – Wilson Farms, we go beyond the traditional office setup. We offer a host of amenities to enhance your work experience, including a spacious executive training room and conference rooms equipped with the latest technology to meet all your meeting and conference needs. Our event space, communal working with standing desk options, private phone booths, wellness rooms, lounge areas, and fully stocked cafe provides a well-rounded environment designed to inspire productivity and collaboration.

Venture X

141 Traction Street

From $348/MO

Discover a dynamic work environment at a state-of-the-art, serviced office and coworking space on Traction Street, Greenville—immerse in a bustling community of professionals where productivity meets comfort. Thoughtfully designed offices offer flexibility and convenience, ensuring an ideal workspace tailored to individual needs. Experience a collaborative atmosphere in the coworking area, fostering networking opportunities and creative exchanges. Enjoy high-speed internet, modern meeting rooms, and ergonomic furniture, all aimed at enhancing the workday. With a prime location in the heart of the West End Historic District, professionals are surrounded by local amenities, trendy cafes, and inspiring cultural hubs. Elevate the work experience at this Traction Street location, where innovation and professionalism converge seamlessly.

Regus Greenville - East Stone Ave

15-17 East Stone Avenue 1st & 2nd Floor

Coworking from $99/MO

Located on East Stone Avenue in Greenville, this flexible coworking space offers a prime address just minutes from downtown, ideal for startups, freelancers, and established businesses seeking a dynamic work environment. Surrounded by popular cafés, retail shops, and well-connected transit routes, the space provides private offices, hot desks, meeting rooms, and breakout areas for productivity and collaboration. High-speed internet, on-site parking, and 24/7 access come standard, while the vibrant local community adds a distinctive energy. East Stone Avenue’s blend of historic charm and modern growth makes it a strategic choice for professionals looking to work smarter in the heart of Greenville’s innovation corridor.

Flywheel Coworking

25, Goldsmith Street

Coworking from $250/MO

This workspace offers a dedicated 10' x 10' private office designed for professionals who need a quiet, focused environment without long-term commitment. The space is available on a flexible month-to-month basis with no lease requirements. Members have 24-hour access year-round, allowing you to work at whatever time suits your schedule. The building features staffed reception during business hours, and your membership includes a set number of meeting room hours at member rates. The facility is fully accessible, with handicap parking available near the main entrance. The building amenities support both work and informal collaboration. There's a well-equipped open kitchen and coffee bar with complimentary tea, coffee, and beer on tap. Additional facilities include an onsite gym, high-speed WiFi, dedicated phone and video conferencing rooms, and free parking. The space is climate-controlled with heating and air-conditioning. After-hours access for 24/7 members is managed through the Open Avigilon app. Staff support is available during standard business hours at the main desk, with ongoing admin and IT support included as part of your membership. This setup works well for solo practitioners, small teams, or anyone seeking a professional office base with flexibility and minimal overhead.

Regus Greenville - Millport Cir

128 Millport Circle Suite 200

Coworking from $409/MO

This fantastic and regionally revered business center establishment is perfectly located in an upscale office development on Butler Road in Greenville – a rapid-growth business area in South Carolina and a district that is prominent for being commercially significant and locally renowned as a central and key business hub. The business center is highly visible and accessible from the I-385 and sits in beautifully landscaped grounds offering plenty of secure parking provision for all prospective tenants and visitors to the site. The interior work spaces, with their wide windows, benefit from lots of natural light.

TKO Suites

777, Lowndes Hill Road

From $395/MO

Located at 777 Lowndes Hill Road, Building 2, Suite 300 in Greenville, South Carolina, this workspace places your business in one of the city’s most accessible and fast-growing commercial corridors. Positioned just off Interstate 385 and Interstate 85, this location offers excellent connectivity throughout Greenville and the broader Upstate region, making commuting simple for both employees and clients traveling from surrounding areas. The surrounding area offers a strong mix of professional conveniences and everyday amenities. Nearby, you’ll find a variety of dining options ranging from quick lunch spots to business-friendly restaurants, along with hotels such as the Hilton and Courtyard by Marriott that provide convenient accommodations for visiting clients. Retail centers, banking services, and fitness facilities are all within a short drive, allowing professionals to handle errands or meetings without leaving the area. Greenville’s vibrant downtown is just minutes away, offering additional opportunities for networking, dining, and entertainment along Main Street and Falls Park on the Reedy. The proximity to Greenville-Spartanburg International Airport also makes this an ideal location for businesses with regional or national travel needs. With its strategic highway access, nearby amenities, and close connection to downtown Greenville, this location provides small businesses and solo professionals with a convenient, professional environment designed to support growth, productivity, and client engagement.

Thrive Coworking

104 S Main Street

Coworking from $110/MO

THRIVE Coworking provides a vibrant workspace with flexible coworking, private offices, and modern meeting rooms tailored for professionals, teams, and remote workers. Enjoy amenities like high-speed WiFi, free coffee and tea, and access to networking events that build community. With 24/7 access, flexible membership options, and a collaborative atmosphere, members can rest assured that their office needs are met in a modern, reliable manner. Thoughtfully designed, THRIVE locations offer the perfect mix of focus and inspiration, creating an environment where productivity and creativity can thrive.

Spaces Greenville - South Main St

355 S Main Street 1st and 2nd Floor

Coworking from $589/MO

This is a workspace that is perfect for startups, and office spaces that are well thought out keeping in mind all kinds of requirements a client needs, such as all-time access to the internet and furniture that is suitable for an office environment. The office space offers amenities like flexible coworking options, designer furniture, fully equipped meeting rooms, and a break-out area. There’s also super-fast WIFI and in-house services. Moreover, the center is open for all the members round the clock seven days a week, making a workplace vibrant and essential for networking and arranging meetings with clients.

Regus Greenville - North Main St

220 North Main Street Suite 500

Coworking from $459/MO

The business center is set in a class-A office, modern mixed-use building. Bellow the business on the ground floor there are many retail units, ideal for a quick browse during your lunch break. The building is connected to a hotel and cite parking garage. The offices themselves are fully furnished and available on flexible terms. Offering executive suites, open-plan office space, coworking communal areas and virtual office options the center offers every type of office space you could possibly require. With on-site facilities such as meeting rooms and a business lounge, which is ideal for relaxed team catch-ups, along with many more facilities available upon request.

Venture X

4900 O’Hear Avenue Suites 100 & 200

Coworking from $399/MO

This business center provides companies with move-in ready, all-inclusive office space, allowing each business to focus on their tasks while being part of a larger community of professionals. Here, the space offers amenities including: Unlimited coffee, High-tech meeting rooms, café offering fresh food and an array of drink options, mail services, cleaning services and free parking. The building itself is accessible 24 hours a day, so is suitable for any kind of business hours! There is also an on-site admin support team who can assist with telephone answering and mail handling letting you focus on work.

Regus Sumter - West Hampton Ave

208 West Hampton Avenue 1st Floor

Coworking from $129/MO

Located on the historic West Hampton Avenue in Sumter, this flexible coworking space offers a dynamic environment for productivity and collaboration. This space caters to freelancers, startups, and businesses seeking a professional yet inspiring setting, featuring high-speed internet, ergonomic workstations, private offices, and modern meeting rooms. It ensures convenience and efficiency with 24/7 access, on-site amenities, and proximity to local dining and retail. Whether for networking, client meetings, or focused solo work, this workspace provides flexibility, comfort, and innovation for professionals looking to thrive.

Regus Bluffton - Traders Cross

110 Traders Cross 1st Floor

Coworking from $429/MO

This professional business center is situated in an attractive two-story building boasting fabulous views. Surrounded by trees and shrubs the building is situated beautifully, while inside the finishes are high-end with a lovely communal areas and a balcony over the entrance, providing a professional and classy appearance, great for impressing your clients. Offering fully furnished executive suites, open-plan office space, coworking communal areas and virtual office options this center has a solution to meet your unique requirements. With on-site facilities including a large parking lot, meeting rooms of varying sizes and a business lounge which is ideal for relaxed team catch-ups.

HQ North Myrtle Beach - 2nd Ave South

1000 2nd Avenue South

Coworking from $339/MO

This is a fully serviced office space that offers everything needed to succeed in business. It has flexible office space with coworking spaces, high-tech conferencing rooms, and breakout areas. It also has reliable and high-speed Wi-Fi for collaboration and partnership opportunities. The cleaning, security, and utilities are taken care of by a friendly support team. The office space is filled with natural light and has breathtaking views of the coastline. This is the ideal place to achieve work-life balance and grow the business. It also has easy access to the beach, art galleries, theatres, and restaurants for leisure and entertainment.

Spaces Summerville - Nexton Sq Dr

700 Nexton Square Drive

Coworking from $129/MO

Nexton Square Drive in Summerville offers a premier, flexible coworking space for modern professionals seeking a dynamic work environment. Situated within the vibrant Nexton Square development, this coworking hub combines convenience, accessibility, and community. It features fully equipped workstations, high-speed internet, private meeting rooms, and collaborative zones tailored for productivity and networking. The location benefits from easy access to major highways, ample parking, and nearby dining and retail options, making it an ideal base for startups, freelancers, and remote teams. Flexible membership plans accommodate varying business needs, fostering growth and innovation. This coworking space perfectly blends professionalism and flexibility in a thriving, pedestrian-friendly setting.

Regus Mount Pleasant - Winnowing Way

1240 Winnowing Way Suite 102

Coworking from $449/MO

This class-A four storey office building boasts an impressive exterior of glass and a contemporary high quality lobby area, all situated in close proximity to the popular area of Mount Pleasant. Offering flexible terms of occupancy on executive suites and corporate office space, there is everything here for your company to flourish and grow successfully in an engaging and highly productive corporate environment. With on-site facilities including a fitness center and swimming pool this exceptional and exquisitely furnished business center has so much to offer; including spacious meeting rooms, high speed internet and on-site management services.

Serendipity Labs

75 Port City Landing Suite 110 and 200

Coworking from $199/MO

The workspace is designed for collaboration and innovation. The center allows companies to choose an ideal solution for a great work life, from private offices, co-working space, and drop-in plans, all supported by an on-site hospitality team. Enjoy the amenities such as AV equipment, bike racks, kitchen, abundant natural light with glass floor-to-ceiling, parking deck, fully furnished and move-in ready, branding opportunities, customization available to meet company standards, a configurable and secure network. The center provides access to on-demand meeting rooms, focus rooms, common areas, and collaboration spaces.

Regus North Charleston - Rivers Ave

5935 Rivers Avenue Suite 104

Coworking from $149/MO

The workspace offers a great and modern working office space with all the required instruments for seamless working, such as front desk reception, 24-hour access, fast internet access, an on-site management team, a fully air-conditioned workspace, and kitchen services available to all users. Equipped with the latest technical technology, state-of-the-art meeting and conferencing facilities, and excellent business services supported by a team of professionals. Elegant lighting, modern furniture, flooring, and services like free beverages and kitchen are in-house, so members can work to their fullest potential.

HQ Hilton Head Island - Office Park Rd

32 Office Park Road

Coworking from $119/MO

Located on Office Park Road in the heart of Hilton Head Island, this flexible coworking space offers the perfect solution for remote workers, entrepreneurs, and small businesses seeking a professional environment with all the modern amenities. With spacious, well-equipped workstations, high-speed internet, and private meeting rooms, this coworking hub caters to individual professionals and teams. Enjoy the convenience of flexible membership options, 24/7 access, and a supportive community that fosters creativity and productivity. Positioned near major roads and local amenities, this coworking space is ideal for anyone looking to thrive in a dynamic work environment.

Regus Aiken - Trl Ridge Rd

900 Trail Ridge Road 1st Floor

Coworking from $149/MO

Experience the convenience and comfort of conducting business in this sophisticated business center which provides a lounge area or holds important meetings in spacious, well-appointed rooms. To ensure the smooth operation of business pursuits, high-speed internet access is readily available. Safety and accessibility are top priorities, hence the 24-hour access and robust security measures. What sets this workspace apart is the breathtaking panoramic views of the surrounding area that will undoubtedly inspire and fuel productivity. Catering to businesses of all sizes and spanning a range of industries, this business center delivers exceptional value without compromising on quality along with ample parking space.

Regus Columbia - Stoneridge Dr

140 Stoneridge Drive

Coworking from $309/MO

The newly designed office space is something different from the traditional, stuffy corporate buildings. The modern, minimalistic style is supposed to help the members focus and be productive but still gives off a homey feeling. Each floor has a kitchenette and bathroom, while the ground floor has meeting rooms and the main bathroom with a shower and changing room. The newly designed building also includes a beautiful reception area in a converted hallway. The top floors are the recreational floors, where the above floors feature a fully equipped kitchen and rooftop access to enjoy countryside views.